Daita G, Yonemasu Y
Department of Neurosurgery, Asahikawa Medical College, Hokkaido.
Neurol Med Chir (Tokyo). 1996 Apr;36(4):211-4. doi: 10.2176/nmc.36.211.
The relationship between invasiveness and proliferative potential was studied in 31 cases of pituitary adenomas. The invasiveness was determined by histological examination of sellar floor dura resected during transsphenoidal surgery. The proliferative potential of adenoma specimens was examined immunohistochemically using monoclonal antibody (MIB-1). There were 11 adenomas with histologically verified dural invasion out of 31 cases. These adenomas had a higher MIB-1- positive ratio than adenomas without dural invasion (p < 0.05). Pituitary adenomas with a high proliferative potential tend to be invasive.
在31例垂体腺瘤中研究了侵袭性与增殖潜能之间的关系。侵袭性通过经蝶窦手术中切除的鞍底硬脑膜的组织学检查来确定。使用单克隆抗体（MIB-1）通过免疫组织化学方法检测腺瘤标本的增殖潜能。31例中有11例腺瘤经组织学证实有硬脑膜侵犯。这些腺瘤的MIB-1阳性率高于无硬脑膜侵犯的腺瘤（p<0.05）。具有高增殖潜能的垂体腺瘤倾向于具有侵袭性。
