[人脑肿瘤中凋亡相关基因产物的表达及诱导凋亡治疗]
[Expression of apoptosis-related gene products in human brain tumors and apoptosis-inducing therapy].
作者信息
Tabuchi K, Shiraishi T, Toda K, Kawaguchi S
机构信息
Department of Neurosurgery, Saga Medical School.
出版信息
Nihon Rinsho. 1996 Jul;54(7):1922-8.
To elucidate the mechanism of apoptosis in brain tumors, we analyzed the expression of apoptosis-related gene products in cultured glioma cells and biopsied brain tumor specimens. Fas, Bcl-2 family (Bcl-2, Bcl-x and Bax) and ICE family (ICE, Ich-1) were found to be involved in tumorigenesis of certain brain tumors. It was also clarified that OK-432 activated mononuclear cells could kill T98G glioblastoma cells by apoptotic mechanism through the Fas ligand/Fas system.
为阐明脑肿瘤细胞凋亡的机制，我们分析了培养的胶质瘤细胞和脑肿瘤活检标本中凋亡相关基因产物的表达。发现Fas、Bcl-2家族（Bcl-2、Bcl-x和Bax）以及ICE家族（ICE、Ich-1）参与了某些脑肿瘤的发生。还阐明了OK-432激活的单核细胞可通过Fas配体/Fas系统，经凋亡机制杀死T98G胶质母细胞瘤细胞。
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