Kurisawa M, Yui N
School of Materials Science, Japan Advanced Institute of Science and Technology.
Nihon Rinsho. 1996 Jul;54(7):2004-11.
Since the concept of sustained release of biologically active agents was established in 1970's, the sustained release has been examined by controlling the diffusion of drugs through polymeric matrices and/or the degradation of these polymers. Recently, drug release in proportion to internal or external stimuli has been getting important, which can be achieved by using stimuli-responsive polymeric materials. Majority of these polymers have been designed as to achieve their functions by changes in temperature, pH, glucose concentration, and the release of ribosomal enzymes. Especially, among those materials, biodegradable polymers have much potential for applications as implantable carriers for drug delivery system (DDS). In an auto feed-back drug delivery, several physiological changes in a living body can be utilized as the signal inducing polymer degradation and subsequent drug release. A hydrogel composed of hydrophilic biomaterials has been focused because of their high responsibility to the stimulus. In this paper, currently investigated DDS using hydrogels are reviewed with their strategies.
自20世纪70年代生物活性剂缓释概念确立以来，人们通过控制药物在聚合物基质中的扩散和/或这些聚合物的降解来研究缓释。最近，与内部或外部刺激成比例的药物释放变得越来越重要，这可以通过使用刺激响应性聚合物材料来实现。这些聚合物中的大多数被设计为通过温度、pH值、葡萄糖浓度的变化以及核糖体酶的释放来实现其功能。特别是，在这些材料中，可生物降解聚合物作为药物递送系统（DDS）的可植入载体具有很大的应用潜力。在自动反馈药物递送中，生物体内的几种生理变化可以用作诱导聚合物降解和随后药物释放的信号。由亲水性生物材料组成的水凝胶因其对刺激的高响应性而受到关注。本文综述了目前使用水凝胶研究的药物递送系统及其策略。
