Baille-Le Crom V, Collombet J M, Carpentier P, Brochier G, Burckhart M F, Foquin A, Pernot-Marino I, Rondouin G, Lallement G
Unite de Neurotoxicologie, Centre de Recherches du Service de Santé des Armées, La Tronche, France.
Neuroreport. 1995 Dec 29;7(1):365-9.
We investigated the time course of GFAP levels in the hippocampal formation during the first 24 h following soman intoxication in rats. GFAP mRNA expression was detected by in situ hybridization. Intense GFAP mRNA expression was present in the molecular layer of the dentate gyrus as early as 6 h after intoxication. This expression was comparatively lower in other dentate gyrus layers and hippocampal CA1, CA3 and CA4 areas and seemed to be related to excessive neuronal activity. Histopathological examination demonstrated that GFAP expression in dentate gyrus is not correlated with lesions. The high astrocytic reactivity in the molecular layer of the dentate gyrus is discussed in relation to the maintenance of the homeostasis of glutamate and of synaptic plasticity in this area during soman intoxication.
我们研究了大鼠梭曼中毒后最初24小时内海马结构中胶质纤维酸性蛋白（GFAP）水平的时间进程。通过原位杂交检测GFAP mRNA表达。中毒后6小时，齿状回分子层就出现了强烈的GFAP mRNA表达。在齿状回的其他层以及海马CA1、CA3和CA4区，这种表达相对较低，并且似乎与过度的神经元活动有关。组织病理学检查表明，齿状回中的GFAP表达与损伤无关。本文讨论了在梭曼中毒期间，齿状回分子层高星形胶质细胞反应性与该区域谷氨酸稳态维持及突触可塑性的关系。
