苯扎氯铵可抑制缓激肽和GlcNAc寡聚体特异性凝集素曼陀罗凝集素诱导的大鼠腹膜肥大细胞释放组胺，但肝素则无此作用。

Benzalkonium chloride inhibited the histamine release from rat peritoneal mast cells induced by bradykinin and GlcNAc oligomer-specific lectin Datura stramonium agglutinin, but heparin did not.

Niitsuma A, Uchida M K, Suzuki-Nishimura T

Department of Molecular Pharmacology, Meiji College of Pharmacy, Tokyo, Japan.

Gen Pharmacol. 1996 Jan;27(1):123-8. doi: 10.1016/0306-3623(95)00082-8.

Abstract

Benzalkonium chloride (BAC) inhibited the histamine release from rat peritoneal mast cells induced by synthetic cationic polymers (compound 48/80 and PEI6), bradykinin, des-Arg1-bradykinin and des-Arg9-bradykinin and Datura stramonium agglutinin (DSA). 2. The anionic polymers heparin, de-N-sulfated heparin, poly-aspartic acid and poly-glutamic acid dose dependently inhibited the histamine release induced by cationic polymers, suggesting counteraction between anions and cations. 3. Inhibition by heparin was diminished but that of BAC remained after removal of extracellular heparin and BAC. 4. Mast cell activation by bradykinin and DSA was not inhibited by anionic polymers, suggesting that both bradykinin and DSA recognize membrane sites as receptors.

摘要

苯扎氯铵（BAC）抑制了由合成阳离子聚合物（化合物48/80和PEI6）、缓激肽、去-Arg1-缓激肽、去-Arg9-缓激肽和曼陀罗凝集素（DSA）诱导的大鼠腹膜肥大细胞组胺释放。2. 阴离子聚合物肝素、去-N-硫酸化肝素、聚天冬氨酸和聚谷氨酸剂量依赖性地抑制了由阳离子聚合物诱导的组胺释放，表明阴离子和阳离子之间存在拮抗作用。3. 去除细胞外肝素和BAC后，肝素的抑制作用减弱，但BAC的抑制作用仍然存在。4. 阴离子聚合物不抑制缓激肽和DSA对肥大细胞的激活，表明缓激肽和DSA都将膜位点识别为受体。