Scorza M C, Reyes-Parada M, Silveira R, Viola H, Medina J H, Viana M B, Zangrossi H, Graeff F G
Division Biología Celular, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.
Pharmacol Biochem Behav. 1996 Jun;54(2):355-61. doi: 10.1016/0091-3057(95)02149-3.
Behavioral effects of the phenethylamine derivative (+/-)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2) were studied in mice and rats. Murine locomotor activity, measured with a photocell actometer, was markedly depressed following IP injection of 2 and 6 mg/kg of the drug. The same doses of the drug also decreased frequency and duration of head dipping and the number of rearings in the hole board apparatus. In the murine elevated plus maze 2 and 6 mg/kg of ALEPH-2 increased the percentage of both open arm entries and time. The total number of entries into the enclosed arms was not significantly affected by the drug. In the rat, 2-12 mg/kg ALEPH-2, IP, decreased photobeam counts in the actometer in a dose-dependent fashion. Both 2 and 4 mg/kg of the drug increased the percentage of open arm entries, but only the highest dose significantly increased the percentage of time spent on the open arms. The dose of 4 mg/kg ALEPH-2 also significantly decreased the total number of enclosed arm entries. Finally, in a recently developed model of anxiety and memory, the elevated T-maze, the doses of 2 and 4 mg/kg ALEPH-2 did not change inhibitory avoidance of the open arms. Nevertheless, the highest dose had an amnestic effect on this task, repeated 72 h later in the absence of drug. In addition, this dose significantly increased the latency to escape from the open arms and had an amnestic effect measured 72 h later. Overall, these results indicate that ALEPH-2 possesses anxiolytic, amnestic as well as sedative and/or motor depressant actions.
对苯乙胺衍生物（±）-1-（2,5-二甲氧基-4-乙硫基苯基）-2-氨基丙烷（ALEPH-2）的行为效应在小鼠和大鼠中进行了研究。腹腔注射2和6mg/kg该药物后，用光电管活动计测量的小鼠自发活动显著降低。相同剂量的药物还减少了在洞板装置中探头和竖尾的频率及持续时间。在小鼠高架十字迷宫中，2和6mg/kg的ALEPH-2增加了进入开放臂的百分比和时间。进入封闭臂的总数未受到该药物的显著影响。在大鼠中，腹腔注射2-12mg/kg的ALEPH-2，以剂量依赖方式减少了活动计中的光束计数。2和4mg/kg的药物均增加了进入开放臂的百分比，但只有最高剂量显著增加了在开放臂上花费的时间百分比。4mg/kg的ALEPH-2剂量也显著减少了进入封闭臂的总数。最后，在最近开发的焦虑和记忆模型——高架T迷宫中，2和4mg/kg的ALEPH-2剂量未改变对开放臂的抑制性回避。然而，最高剂量对该任务有遗忘作用，在72小时后无药物情况下重复测试时出现。此外，该剂量显著增加了从开放臂逃脱的潜伏期，并在72小时后测量时有遗忘作用。总体而言，这些结果表明ALEPH-2具有抗焦虑、遗忘以及镇静和/或运动抑制作用。
