Bennett J A, Keck P E
Department of Psychiatry, University of Cincinnati College of Medicine, Ohio, USA.
Ann Clin Psychiatry. 1996 Mar;8(1):19-21. doi: 10.3109/10401239609149086.
Evidence from recent studies suggests that clozapine plasma concentrations greater than 350 ng/ml are correlated with therapeutic response. However, little is known about the clozapine dosages required to achieve these plasma concentrations. The purpose of this study was to determine if a target dose of 6 mg/kg/day of clozapine would produce a steady state plasma concentration of > 350 ng/ml. Twelve patients with schizophrenia by DSM-III-R criteria who were refractory to treatment with standard antipsychotics were treated with clozapine utilizing a 10- to 14-day titration to a target dose of 6 mg/kg/day. The mean (+/- SD) clozapine plasma concentration achieved after 5 days at the target dose was 584 +/- 417 ng/ml. Thus, although the target dose successfully produced therapeutic plasma concentrations for most patients, a wide variation was also apparent.
近期研究证据表明，氯氮平血浆浓度大于350 ng/ml与治疗反应相关。然而，对于达到这些血浆浓度所需的氯氮平剂量却知之甚少。本研究的目的是确定氯氮平6 mg/kg/天的目标剂量是否会产生> 350 ng/ml的稳态血浆浓度。根据DSM-III-R标准诊断为精神分裂症且对标准抗精神病药物治疗无效的12名患者，接受氯氮平治疗，采用10至14天的滴定法达到6 mg/kg/天的目标剂量。在目标剂量下5天后测得的氯氮平血浆平均（±标准差）浓度为584±417 ng/ml。因此，尽管目标剂量成功地使大多数患者产生了治疗性血浆浓度，但个体差异也很明显。
