Chang M L, Bang N U
J Lab Clin Med. 1977 Jul;90(1):216-26.
We have examined the consequence of infusions into rabbits of the products of limited plasmin hydrolysis of fibrin (early fibrin degradation products, or early fdp) containing defined quantities of fibrin fragment X. For comparison, early fibrinogen degradation products (early FDP) and late fibrin degradation products (late fdp) consisting almost exclusively of core fragments D and E were infused into separate groups of animals. Components of early fdp, probably fibrin fragment X, behaved in many respects like fibrin monomer. Infused unlabeled early fdp produced circulating soluble fibrin complexes with 125I-labeled fibrinogen. 125I-labeled early fdp rapidly accumulated in the spleen and liver and also to a significant degree in the lungs as insoluble, nonextractable tissue-bound protein; in contrast, only minimal quantities of early FDP and late fdp accumulated in organs. When 125I-labeled early fdp were administered to animals given continuous infusions of epsilon-aminocaproic acid to block fibrinolysis, substantial amounts of radioisotope also accumulated in the kidneys. These observations suggest a possible pathophysiological role for the products of lysing fibrin encountered in clinical states associated with disseminated intravascular coagulation.
我们研究了向兔子输注含有一定量纤维蛋白片段X的有限纤溶酶水解纤维蛋白产物（早期纤维蛋白降解产物，即早期FDP）的后果。作为比较，将几乎完全由核心片段D和E组成的早期纤维蛋白原降解产物（早期FDP）和晚期纤维蛋白降解产物（晚期FDP）分别输注到不同组的动物体内。早期FDP的成分，可能是纤维蛋白片段X，在许多方面表现得像纤维蛋白单体。输注未标记的早期FDP会与125I标记的纤维蛋白原形成循环可溶性纤维蛋白复合物。125I标记的早期FDP迅速在脾脏和肝脏中积累，并且在肺中也大量积累，形成不溶性、不可提取的组织结合蛋白；相比之下，只有少量的早期FDP和晚期FDP在器官中积累。当向持续输注ε-氨基己酸以阻断纤溶的动物施用125I标记的早期FDP时，大量放射性同位素也在肾脏中积累。这些观察结果表明，在与弥散性血管内凝血相关的临床状态下遇到的纤维蛋白溶解产物可能具有病理生理作用。
