Bozhinova S, Porozhanova V, Popovski K, Bozhinov P, Atanasova S
Akush Ginekol (Sofiia). 1995;34(3):1-4.
The authors aimed at studying the local application of PgE2 as a method of labor induction. 50 pregnant women divided into 3 groups were studied: I with Prostin E2 - vaginal tablets of 3 mg. Dinoprostone. II with Prepidil gel - 0.5 mg. Dinfprostone, applied intracervically and III with additional stimulation with Oxytocin - 5 E as an i.v. infusion. The criteria used were: parity, gestational age, Bishop score indications for induction. Success is considered as normal delivery by the 24th hour. Indications for PgE2 application are prematurity praeeclampsia, fetal malformations, fetal death, grave obstetrics history, RH incompatibility. It was discovered that with Prostin E2, the active phase of labor is reduced thus leading to reduction of labor. The frequency of operative deliveries also reduced and there were better fetal outcome. Two important advantages were discovered--simple application and physiologic advantages--the woman in labor is mobile and thus not traumatised. The authors stress that PgE2 application can be considered an effective method for labor induction.
作者旨在研究将前列腺素E2（PgE2）局部应用作为引产方法。对50名孕妇进行了分组研究：第一组使用普罗斯特E2（Prostin E2）——3毫克地诺前列酮阴道片；第二组使用普瑞迪尔凝胶（Prepidil gel）——0.5毫克地诺前列酮，宫颈内给药；第三组使用缩宫素5单位静脉输注进行额外刺激。所采用的标准为：产次、孕周、引产的 Bishop评分指征。成功定义为在24小时内顺产。应用PgE2的指征包括早产、先兆子痫、胎儿畸形、胎儿死亡、严重产科病史、Rh血型不合。研究发现，使用普罗斯特E2时，产程活跃期缩短，从而导致总产程缩短。手术分娩的频率也降低了，且胎儿结局更好。发现了两个重要优点——应用简单和生理优势——产妇在分娩过程中可活动，因此不会受到创伤。作者强调，应用PgE2可被视为一种有效的引产方法。
