Murawaki Y, Ikuta Y, Nishimura Y, Koda M, Kawasaki H
Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
J Gastroenterol Hepatol. 1996 May;11(5):443-50. doi: 10.1111/j.1440-1746.1996.tb00289.x.
In order to elucidate collagen metabolism in hepatocellular carcinoma (HCC) tissue, we compared levels of different potential markers of collagen metabolism and plasma transforming growth factor-beta 1 in patients with HCC and in patients with liver cirrhosis. Serum levels of prolyl hydroxylase and the tissue inhibitor of metalloproteinase-1 in patients with HCC were significantly higher than those in patients with liver cirrhosis and increased with the size of the HCC tumour, whereas the serum levels of procollagen type III propeptide and type IV collagen 7S domain were similar in the two groups. In HCC, the increased plasma transforming growth factor-beta 1 levels were closely correlated with serum levels of prolyl hydroxylase and the tissue inhibitor of metalloproteinase-1. These findings suggest that, in HCC tissue, the intracellular biosynthesis of collagen is enhanced, whereas the secretion of procollagen is disturbed and the degradation of collagen is suppressed by the excess production of the tissue inhibitor of metalloproteinase-1. The results also suggest that plasma transforming growth factor-beta 1 plays an important role in the altered metabolism of collagen in HCC.
为了阐明肝细胞癌（HCC）组织中的胶原蛋白代谢情况，我们比较了HCC患者和肝硬化患者中不同潜在胶原蛋白代谢标志物的水平以及血浆转化生长因子-β1的水平。HCC患者血清中的脯氨酰羟化酶和金属蛋白酶组织抑制剂-1水平显著高于肝硬化患者，且随HCC肿瘤大小增加而升高，而两组中III型前胶原肽和IV型胶原7S结构域的血清水平相似。在HCC中，血浆转化生长因子-β1水平升高与脯氨酰羟化酶和金属蛋白酶组织抑制剂-1的血清水平密切相关。这些发现表明，在HCC组织中，胶原蛋白的细胞内生物合成增强，而前胶原的分泌受到干扰，并且金属蛋白酶组织抑制剂-1的过量产生抑制了胶原蛋白的降解。结果还表明，血浆转化生长因子-β1在HCC中胶原蛋白代谢改变中起重要作用。
