文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lambert J J, Belelli D, Hill-Venning C, Callachan H, Peters J A

Department of Pharmacology & Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, Scotland.

Cell Mol Neurobiol. 1996 Apr;16(2):155-74. doi: 10.1007/BF02088174.

The pioneering work of Hans Selye over 50 years ago demonstrated that certain steroid metabolites can produce a rapid depression of central nervous system activity. 2. Research during the last 10 years has established that such effects are mediated by a nongenomic and specific interaction of these steroids with the brain's major inhibitory receptor, the GABAA receptor. 3. Here we describe the molecular mechanism of action of such steroids and review attempts to define the steroid binding site on the receptor protein. The therapeutic potential of such neurosteroids is discussed.

50多年前汉斯·塞尔耶的开创性研究表明，某些类固醇代谢产物可迅速抑制中枢神经系统活动。2. 过去10年的研究证实，这些效应是由这些类固醇与大脑主要抑制性受体——γ-氨基丁酸A型（GABAA）受体的非基因组特异性相互作用介导的。3. 在此，我们描述此类类固醇的分子作用机制，并综述确定受体蛋白上类固醇结合位点的尝试。还讨论了此类神经类固醇的治疗潜力。

Lambert J J, Belelli D, Hill-Venning C, Callachan H, Peters J A

Department of Pharmacology & Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, Scotland.

Cell Mol Neurobiol. 1996 Apr;16(2):155-74. doi: 10.1007/BF02088174.

The pioneering work of Hans Selye over 50 years ago demonstrated that certain steroid metabolites can produce a rapid depression of central nervous system activity. 2. Research during the last 10 years has established that such effects are mediated by a nongenomic and specific interaction of these steroids with the brain's major inhibitory receptor, the GABAA receptor. 3. Here we describe the molecular mechanism of action of such steroids and review attempts to define the steroid binding site on the receptor protein. The therapeutic potential of such neurosteroids is discussed.

50多年前汉斯·塞尔耶的开创性研究表明，某些类固醇代谢产物可迅速抑制中枢神经系统活动。2. 过去10年的研究证实，这些效应是由这些类固醇与大脑主要抑制性受体——γ-氨基丁酸A型（GABAA）受体的非基因组特异性相互作用介导的。3. 在此，我们描述此类类固醇的分子作用机制，并综述确定受体蛋白上类固醇结合位点的尝试。还讨论了此类神经类固醇的治疗潜力。