Overgaard H, Timshel S
Organkirurgisk afdeling, Sundby Hospital, København.
Ugeskr Laeger. 1996 May 6;158(19):2717-8.
We report a case where a patient developed recurrence of an adenocarcinoma of the stomach ten years after primary surgery. Besides the late recurrence, the case is interesting as the patient participated in a trial investigating the effect of cimetidine on survival after gastric cancer and received cimetidine for two years after surgery. Considering the well documented anti-tumour and immunomodulating effects of histamine type-2 receptor antagonists, it might be interesting to examine the effect on survival after surgery for gastric cancer in patients receiving prolonged treatment with such an antagonist.
我们报告了一例患者,该患者在初次手术后十年出现胃腺癌复发。除了复发较晚外,该病例还很有意思,因为患者参与了一项研究西咪替丁对胃癌患者生存影响的试验,并在术后接受了两年的西咪替丁治疗。鉴于组胺2型受体拮抗剂的抗肿瘤和免疫调节作用已有充分记录,研究长期接受此类拮抗剂治疗的患者在胃癌手术后的生存影响可能会很有趣。