Kuznetsova A G, Larin N V, Ivanov A V
Ter Arkh. 1996;68(3):62-5.
This study aimed at clarification of pathophysiological mechanisms underlying bronchial obstruction in 28 18-71-year-old patients with chronic bronchitis (CB) diagnosed 2-8 years before. The patients had moderate obstructive disorders in distal parts of the bronchial tree. Investigations revealed a group of patients with paradoxical response to beta-blockers manifesting as lowering of bronchial resistance and high speed. Bronchial obstruction in these patients proved to arise primarily from early expiratory collapse of small bronchi. Administration of beta-mimetic and beta-blocking agents may serve as pharmacological tests able to discover mechanisms of bronchial obstruction and help in the choice of adequate therapy for chronic bronchitis.
本研究旨在阐明28例年龄在18至71岁之间、于2至8年前被诊断为慢性支气管炎（CB）的患者支气管阻塞的病理生理机制。这些患者在支气管树远端存在中度阻塞性疾病。研究发现，有一组患者对β受体阻滞剂呈现矛盾反应，表现为支气管阻力降低和气流速度加快。这些患者的支气管阻塞主要源于小支气管早期呼气性塌陷。给予β受体激动剂和β受体阻滞剂可作为药理学试验，有助于发现支气管阻塞的机制，并辅助选择慢性支气管炎的适当治疗方法。
