Gościcka T, Walencka M, Szeliga J, Bloch M, Dziadek B
Department of Immunology, University of Lódź, Poland.
Arch Immunol Ther Exp (Warsz). 1995;43(5-6):239-45.
Listeria innocua can intensify the development of local GvH reaction in a semiallogeneic system in mice. This phenomenon is observed in (BALB/c x AKR)F1 mice intraperitoneally injected with the live bacteria on the 7th day before the transfer of BALB/c spleen cells. The local GvH reaction develops as strongly as in normal hybrid recipients given the parental cell graft in the presence of exogenous interleukin 2 (IL-2). The development of the reaction is associated with an intensive increase of the direct cytotoxicity of lymph node cells which is also markedly enhanced after the bacteria injection itself. IL-2 seems to play a relevant role in the development of local GvH reaction in L. innocua-injected mice.
无害李斯特菌可增强小鼠半同种异体系统中局部移植物抗宿主反应的发展。在将BALB/c脾细胞移植前7天腹腔注射活细菌的（BALB/c×AKR）F1小鼠中观察到这种现象。局部移植物抗宿主反应的发展与正常杂种受体在存在外源性白细胞介素2（IL-2）的情况下接受亲代细胞移植时一样强烈。该反应的发展与淋巴结细胞直接细胞毒性的强烈增加有关，在注射细菌后这种毒性也明显增强。IL-2似乎在注射无害李斯特菌的小鼠局部移植物抗宿主反应的发展中起相关作用。
