Lewandowicz J, Dabkowska B, Nowak D
Division of Rheumatology, Medical Academy, Lódź, Poland.
Arch Immunol Ther Exp (Warsz). 1995;43(3-4):195-8.
Eighteen subjects (2 males, 16 females) with rheumatoid arthritis were treated with gold salts for 6 months. The statistically significant decrease of IL-1 and IL-2 levels during the treatment was observed. The mean serum concentrations of IL-1 and IL-2 decreased from 41.0 +/- 11.5 to 28.6 +/- 7.3 (p < 0.001) and 98.3 +/- 57.6 to 29.3 +/- 20.5 fmol/ml (p < 0.001), respectively. This decrease was accompanied by a decline of serum concentration of acute phase proteins and immunoglobulins. These results can explain a strong anti-inflammatory action of gold salts in patients with rheumatoid arthritis.
18名类风湿性关节炎患者（2名男性，16名女性）接受了金盐治疗6个月。治疗期间观察到IL-1和IL-2水平有统计学意义的下降。IL-1和IL-2的平均血清浓度分别从41.0±11.5降至28.6±7.3（p<0.001）和98.3±57.6降至29.3±20.5 fmol/ml（p<0.001）。这种下降伴随着急性期蛋白和免疫球蛋白血清浓度的下降。这些结果可以解释金盐对类风湿性关节炎患者的强大抗炎作用。
