大鼠和兔离体血管对去甲肾上腺素收缩反应的年龄相关性变化。

Age-related changes in contractile responses to noradrenaline in isolated blood vessels from rat and rabbit.

Carvajal A, Velasco A, Martín Arias L H, Maroto M

Department of Pharmacology, School of Medicine, Valladolid, Spain.

J Auton Pharmacol. 1995 Oct;15(5):321-6. doi: 10.1111/j.1474-8673.1995.tb00398.x.

Abstract

Age-related changes in vascular function have been studied using rat (1, 6 and 10 months) and rabbit (1 and 6 months) isolated aorta and rat (1, 6 and 10 months) mesenteric perfused artery. 2. The EC50 values of noradrenaline in rat aorta increased with age. Similarly, contractile response to noradrenaline (10(-6) M) and potassium (80 mM) increased with age. In rabbit aorta, contractile responses, both for noradrenaline and potassium, decreased with age. No changes were observed with age in sensitivity to noradrenaline in rat mesenteric perfused artery. 3. The results of the present study suggest that age-related changes may be different for different blood vessels. The sensitivity decrease to noradrenaline in rat aorta involved postreceptor mechanisms.

摘要

已使用大鼠（1、6和10个月龄）和兔（1和6个月龄）的离体主动脉以及大鼠（1、6和10个月龄）的肠系膜灌注动脉研究了血管功能的年龄相关变化。2. 大鼠主动脉中去甲肾上腺素的半数有效浓度（EC50）值随年龄增加而升高。同样，对去甲肾上腺素（10⁻⁶ M）和钾（80 mM）的收缩反应也随年龄增加。在兔主动脉中，去甲肾上腺素和钾的收缩反应均随年龄降低。大鼠肠系膜灌注动脉对去甲肾上腺素的敏感性未随年龄发生变化。3. 本研究结果表明，不同血管的年龄相关变化可能不同。大鼠主动脉对去甲肾上腺素敏感性降低涉及受体后机制。