狗胃肠道中肠神经肽YY的分布

Distribution of enteric neural peptide YY in the dog gastrointestinal tract.

作者信息

Iesaki K, Sakai T, Satoh M, Haga N, Koyama H, Itoh Z

机构信息

Gastrointestinal Research Laboratory, Gunma University, Japan.

出版信息

Peptides. 1995;16(8):1395-402. doi: 10.1016/0196-9781(95)02031-4.

DOI:10.1016/0196-9781(95)02031-4

PMID:8745049

Abstract

Various regions of the dog gastrointestinal tract were investigated for the distribution of peptide YY (PYY) neurons using immunocytochemistry and radioimmunoassay. PYY neurons that encircled non-PYY-immunoreactive neurons were mainly observed in the myenteric plexus from the stomach to the colon. There was more PYY-like immunoreactivity in the muscle layer of the stomach and ileum than in the other intestines. The results of high performance liquid chromatography revealed that neural PYY-immunoreactive substance is identical to authentic PYY. PYY was not localized in the cholinergic neurons. These results indicate that PYY, as a neuropeptide, is involved in the regulation of gastrointestinal function.

摘要

利用免疫细胞化学和放射免疫分析法，对犬胃肠道的不同区域进行了肽YY（PYY）神经元分布的研究。环绕非PYY免疫反应性神经元的PYY神经元主要见于从胃到结肠的肌间神经丛。胃和回肠肌层中的PYY样免疫反应性比其他肠段更多。高效液相色谱分析结果显示，神经PYY免疫反应性物质与天然PYY相同。PYY不在胆碱能神经元中定位。这些结果表明，PYY作为一种神经肽，参与胃肠道功能的调节。