胃动素对兔空肠L-亮氨酸转运的影响。

Effect of motilin on the L-leucine transport in rabbit jejunum.

作者信息

Marco R, Navarro H, Rodriguez-Yoldi M J, Sorribas V, Alcalde A I

机构信息

Department of Fisiología, Facultad de Veterinaria, Universidad de Zaragoza, Spain.

出版信息

Peptides. 1995;16(8):1505-10. doi: 10.1016/0196-9781(95)02043-8.

DOI:10.1016/0196-9781(95)02043-8

PMID:8745065

Abstract

Motilin is a gastrointestinal peptide that stimulates the gastrointestinal motility in several species. The aim of the present work has been to determine the effect of motilin on the L-leucine absorption in rabbit jejunum. The results show that motilin inhibits the L-leucine Na(+)-dependent system of transport located in the mucosal border mainly by diminishing the apparent Vmax. Motilin did not directly affect the Na(+)-dependent system of transport, but it seems to act across the protein kinase C (PKC). These results suggest that motilin may act as a regulatory hormone of the intestinal absorption of nutrients.

摘要

胃动素是一种胃肠肽，可刺激多种物种的胃肠蠕动。本研究的目的是确定胃动素对兔空肠中L-亮氨酸吸收的影响。结果表明，胃动素主要通过降低表观最大反应速度来抑制位于黏膜边界的L-亮氨酸钠依赖性转运系统。胃动素并未直接影响钠依赖性转运系统，但它似乎是通过蛋白激酶C（PKC）起作用。这些结果表明，胃动素可能作为营养物质肠道吸收的调节激素发挥作用。