Fukasawa H, Kikkawa F, Tamakoshi K, Kawai M, Arii Y, Tomoda Y
Department of Obstetrics and Gynecology, Shizuoka Saiseikai Hospital, Japan.
Int J Gynaecol Obstet. 1995 Dec;51(3):239-45. doi: 10.1016/0020-7292(95)80014-x.
To elucidate the effects of lymphadenectomy on the prognosis for ovarian cancer.
A retrospective study of 69 patients with stage-III serous cystadenocarcinoma was performed.
Among the 69 patients, 36 were not treated by lymphadenectomy. Both pelvic and para-aortic lymphadenectomies were performed on 13 patients at the initial operation and on 11 at the second operation. The group (n = 13) treated by both pelvic and para-aortic lymphadenectomies at the initial operation had a disease-free survival rate that was significantly higher than the non-lymphadenectomy group (n = 36) or the group (n = 5) treated by pelvic or para-aortic lymphadenectomy alone (P < 0.04). These 54 patients were subjected to multivariate analysis for lymphadenectomy at the initial operation, and a significant correlation was found between disease-free survival rate and both pelvic and para-aortic lymphadenectomies (P < 0.05).
These results suggest that systematic lymphadenectomy can reduce the rate of recurrence.
阐明淋巴结清扫术对卵巢癌预后的影响。
对69例Ⅲ期浆液性囊腺癌患者进行回顾性研究。
69例患者中，36例未行淋巴结清扫术。13例患者在初次手术时同时进行了盆腔和腹主动脉旁淋巴结清扫，11例在二次手术时进行了清扫。初次手术时同时进行盆腔和腹主动脉旁淋巴结清扫的组（n = 13）的无病生存率显著高于未行淋巴结清扫术的组（n = 36）或仅行盆腔或腹主动脉旁淋巴结清扫的组（n = 5）（P < 0.04）。对这54例患者初次手术时的淋巴结清扫情况进行多因素分析，发现无病生存率与盆腔和腹主动脉旁淋巴结清扫均显著相关（P < 0.05）。
这些结果表明，系统性淋巴结清扫术可降低复发率。
