Edwards R G
London Women's Clinic, London and Churchill College, Cambridge, UK.
Hum Reprod. 1995 Dec;10 Suppl 2:60-6. doi: 10.1093/humrep/10.suppl_2.60.
An improvement in clinical pregnancy rate follows a natural or induced period of amenorrhoea. The cause is unknown, but it could be related to the period of uterine 'rest' which may restore full function to the steroid-sensitive systems, such as the pinopodes, after a prolonged period of constant menstrual cycling. This may result in the restoration of uterine capacity for embryo implantation to levels typical of younger women. Some other avenues of research on the unusual aspects of human implantation are worth further study. An impaired uterine blood flow could lower the chances of implantation. Immunological factors may emerge as major elements in the human implantation process, because the neutralization of antiphospholipid antibodies may enhance the activity of early trophoblast.
自然或诱导闭经一段时间后临床妊娠率会有所提高。其原因尚不清楚，但可能与子宫的“休息”期有关，在长期持续的月经周期后，这可能会使对类固醇敏感的系统（如微绒毛）恢复全部功能。这可能会使子宫的胚胎着床能力恢复到年轻女性典型的水平。关于人类着床异常方面的其他一些研究途径值得进一步探讨。子宫血流受损可能会降低着床几率。免疫因素可能会成为人类着床过程中的主要因素，因为抗磷脂抗体的中和可能会增强早期滋养层的活性。
