Du D, Wang W, Luo G
Affiliated Hospital, Guangdong Medical College, Zhanjiang.
Zhonghua Fu Chan Ke Za Zhi. 1995 Nov;30(11):662-4.
To observe the relationship between the filtration-index of erythrocytes and concentration of erythrocytic superoxide dismutase (SOD), plasma malonyldialdehyde (MDA) in cases of pregnancy induced hypertension (PIH).
We have measured the level of MDA and filtration-index, SOD content of erythrocytes in maternal and cord blood of 31 cases with PIH (group A) and 25 cases of normal pregnancy (group B) using TBA method, nucleopore membraned cell deformability meter and pyrogallol self-oxidizing method.
The mean filtration-index level and erythrocytic SOD were significantly higher in group A than those of group B (P < 0.01 and P < 0.05). The mean content of plasmatic MDA in group A increased markedly (P < 0.01) compared to that of group B. There was no difference of these parameters in cord blood between group A and group B.
The decrease of red cell deformability due to the increase of plasma MDA level may be the underlying mechanism of PIH.
观察妊娠高血压综合征（PIH）患者红细胞滤过指数与红细胞超氧化物歧化酶（SOD）浓度、血浆丙二醛（MDA）之间的关系。
采用硫代巴比妥酸（TBA）法、核孔膜细胞变形能力测定仪及邻苯三酚自氧化法，检测31例PIH患者（A组）及25例正常妊娠孕妇（B组）母血及脐血中MDA水平、滤过指数、红细胞SOD含量。
A组平均滤过指数水平及红细胞SOD明显高于B组（P<0.01和P<0.05）。A组血浆MDA平均含量较B组显著升高（P<0.01）。A组与B组脐血中这些参数无差异。
血浆MDA水平升高导致红细胞变形能力下降可能是PIH的潜在发病机制。
