Zhao X, Guan Z
PLA General Hospital, Beijing.
Zhonghua Fu Chan Ke Za Zhi. 1995 Nov;30(11):670-2.
To investigate the prognosis of patients of hydatidiform mole (HM) who complicated with pregnancy induced hypertension (PIH) and to suggest that PIH may serve as a risk factor for malignant change in molar pregnancy.
From 1962 to 1992, 161 patients of HM including 33 cases with PIH and 128 cases of normotension were managed and followed at the PLA General Hospital. The definition of malignant sequelae was that abnormal hCG level was lasting at least 8 weeks after molar evacuation or metastatic lesions was found.
15 of 33 patients with PIH developed metastatic invasive moles (45.5%) and 13 of them metastatic tumors were found before molar evacuation. 12 of 128 cases of normotension had malignant thanges including 1 choriocarcinoma and 11 invasive mole (9.4%) and among them only one had metastatic lesions before molar evacuation.
The incidence (45.5%) of malignant changes in patients complicated with PIH was significantly higher than that in normotensive patients (9.4%) (P < 0.01). In addition, they had early metastatic lesions. This study suggests that PIH may serve as a risk factor for malignant change in molar pregnancy.
探讨葡萄胎（HM）合并妊娠高血压综合征（PIH）患者的预后，并提示PIH可能是葡萄胎恶变的一个危险因素。
1962年至1992年，解放军总医院对161例葡萄胎患者进行了管理和随访，其中33例合并PIH，128例血压正常。恶变后遗症的定义为葡萄胎清宫后异常hCG水平持续至少8周或发现转移病灶。
33例合并PIH的患者中有15例发生了转移性侵袭性葡萄胎（45.5%），其中13例在葡萄胎清宫前发现转移瘤。128例血压正常的患者中有12例发生恶变，包括1例绒毛膜癌和11例侵袭性葡萄胎（9.4%），其中只有1例在葡萄胎清宫前有转移病灶。
合并PIH的患者恶变发生率（45.5%）显著高于血压正常的患者（9.4%）（P<0.01）。此外，他们有早期转移病灶。本研究提示PIH可能是葡萄胎恶变的一个危险因素。
