Chevallier M, Degott C
Laboratoire d'Anatomie Pathologique, Institut Pasteur de Lyon.
Pathol Biol (Paris). 1995 Oct;43(8):703-8.
In patients with C virus, liver biopsy is an essential examination for diagnosis of chronic hepatitis. This examination evaluates the two basic lesions of the disease: aggressivity and fibrosis. During antiviral treatment, only liver biopsy is able to give precise details about liver lesions and no reliable serum test is yet available for the follow-up. Molecular biology methods applied to liver sections for viral genome detection will be of great interest for follow up and pathophysiology of the chronic disease. These sensitive techniques will supply absence of any pathognomonic histological feature associated with C virus in liver tissue.
对于丙型肝炎患者，肝活检是诊断慢性肝炎的重要检查。该检查可评估疾病的两个基本病变：侵袭性和纤维化。在抗病毒治疗期间，只有肝活检能够提供有关肝脏病变的精确细节，目前尚无可靠的血清检测用于随访。应用于肝组织切片以检测病毒基因组的分子生物学方法对于该慢性病的随访和病理生理学研究将具有重要意义。这些敏感技术将揭示肝组织中不存在与丙型肝炎病毒相关的任何特征性组织学特征。
