Hoang-Xuan K, Li Y J, Hamelin R, Delattre O
Service de Neurologie, Hôpital de la Salpêtrière, Paris.
Rev Neurol (Paris). 1995 Nov;151(11):608-18.
Meanwhile first gene therapy assays in cerebral gliomas are in progress, we present in this article a review of the major genetic aberrations reported to date in these tumors. The analysis of these alterations enabled, these last few years, significative advances in the understanding of the mechanisms involved in glioma tumorigenesis. It is now well recognized that tumors result from a multistep process requiring in particular proto-oncogenes activation and tumor suppressor genes inactivation. The different genes implicated in the development of gliomas, their place in the tumoral progression and their potential therapeutic relevance are detailed in this review. The continuation of the identification of glioma altered genes is essential to provide new diagnostic and pronostic markers, and specific targets for more efficient therapy.
与此同时，针对脑胶质瘤的首批基因治疗试验正在进行中，我们在本文中对迄今为止报道的这些肿瘤中的主要基因畸变进行综述。对这些改变的分析在过去几年中推动了我们对胶质瘤肿瘤发生机制认识的显著进展。现在人们已经充分认识到，肿瘤是一个多步骤过程的结果，尤其需要原癌基因激活和肿瘤抑制基因失活。本综述详细介绍了与胶质瘤发生发展相关的不同基因、它们在肿瘤进展中的作用及其潜在的治疗相关性。持续鉴定胶质瘤相关改变基因对于提供新的诊断和预后标志物以及更有效治疗的特定靶点至关重要。
