[用α干扰素治疗转移性类癌肿瘤。5例报告]
[Treatment of metastatic carcinoid tumors with interferon-alpha. Five cases].
作者信息
Votte A, Iglicki F, Sévenet F, Tabah I, Dupas J L
机构信息
Service d'Hépato-Gastroentérologie, CHU Nord, Amiens.
出版信息
Presse Med. 1996 Jan 20;25(2):63-7.
OBJECTIVE
Interferon has been proposed in treatment of metastatic carcinoid tumours with varied results.
METHOD
Five patients with metastatic carcinoid tumours were treated for 1 year with rIFN alpha 2b at a dose of 5 MU. three times a week during the first month and 10 MU. three times a week during the following months. Carcinoid syndrome was present in all cases.
RESULTS
Clinical response with improvement of diarrhoea and flushs was obtained in all cases. Urinary excretion of 5 HIAA and blood serotonin were reduced in 2/5 and 4/5 patients respectively. IFN treatment led to a stabilization of the metastatic tumour in all cases. Recurrence of symptoms was observed within three months following the end of the IFN treatment.
CONCLUSION
These findings confirm the contribution of IFN in the treatment of metastatic carcinoid tumours.
目的
已有人提出用干扰素治疗转移性类癌肿瘤，但其结果各异。
方法
5例转移性类癌肿瘤患者接受了1年的重组干扰素α2b治疗，第1个月剂量为5MU，每周3次，随后几个月剂量为10MU，每周3次。所有病例均存在类癌综合征。
结果
所有病例均出现临床反应，腹泻和潮红症状得到改善。5-羟吲哚乙酸（5-HIAA）的尿排泄量和血液中血清素水平分别在2/5和4/5的患者中降低。干扰素治疗使所有病例的转移性肿瘤病情稳定。在干扰素治疗结束后3个月内观察到症状复发。
结论
这些发现证实了干扰素在治疗转移性类癌肿瘤中的作用。
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