Vandel B, Perault M C
Service de Pharmacologie Clinique, Centre Hospitalier Régional Universitaire, Poitiers, France.
Therapie. 1995 Nov-Dec;50(6):511-3.
The therapeutic drug monitoring of antidepressant drugs is of interest to adapt dosage regimens to reduce the number of non-responder patients, to reduce drug side effects and to detect non-compliant patients. A therapeutic range is defined for many of these drugs and their linear or non-linear kinetics are important parameters in clinical practice to define the posology. Some patients, because of when there is drug biotransformation polymorphism, are exposed to drug accumulation a deficit in isoenzymes of cytochrome P450. The existence of these isoenzymes explains the possibility of non-linear kinetics and drug interactions.
对抗抑郁药物进行治疗药物监测有助于调整给药方案，以减少无反应患者的数量、降低药物副作用并发现不依从治疗的患者。许多这类药物都定义了治疗范围，其线性或非线性动力学是临床实践中确定剂量的重要参数。一些患者由于存在药物生物转化多态性，会因细胞色素P450同工酶缺乏而出现药物蓄积。这些同工酶的存在解释了非线性动力学和药物相互作用的可能性。
