Sinaiko A R, Mirkin B L
J Pediatr. 1977 Jul;91(1):138-42. doi: 10.1016/s0022-3476(77)80466-6.
The therapeutic efficacy of four antihypertensive regimens (minoxidil, propranolol, and hydrochlorothiazide; propranolol and hydrochlorothiazide; methyldopa and hydroch-orothiazide; and hydrochlorothiazide alone) was evaluated in one child with systolic hypertension and in eight children with systolic and diastolic hypertension. The mean blood pressure of 148/98+/-8/4 mm Hg observed during the hydrochlorothiazide control period fell to 142/88+/-8/4 mm Hg following methyldopa and hydrochlorothiazide, 141/85+/-6/2 mm Hg following propranolol and hydrochlorothiazide, and 128/74+/-4/2 mm Hg following minoxidil, propranolol, and hydrochlorothiazide. The only side effect directly associated with administration of minoxidil was hypertrichosis. The effectiveness of minoxidil in the present study suggests that this drug offers an important adjunct to current antihypertensive therapy in children.
对一名收缩期高血压患儿和八名收缩期及舒张期高血压患儿评估了四种抗高血压方案（米诺地尔、普萘洛尔和氢氯噻嗪；普萘洛尔和氢氯噻嗪；甲基多巴和氢氯噻嗪；以及单独使用氢氯噻嗪）的治疗效果。在氢氯噻嗪对照期观察到的平均血压为148/98±8/4 mmHg，在甲基多巴和氢氯噻嗪治疗后降至142/88±8/4 mmHg，在普萘洛尔和氢氯噻嗪治疗后降至141/85±6/2 mmHg，在米诺地尔、普萘洛尔和氢氯噻嗪治疗后降至128/74±4/2 mmHg。与米诺地尔给药直接相关的唯一副作用是多毛症。米诺地尔在本研究中的有效性表明，该药为目前儿童抗高血压治疗提供了一种重要的辅助药物。
