Nicotera P, Bonfoco E, Brüne B
Faculty of Biology, University of Konstanz, Germany.
Adv Neuroimmunol. 1995;5(4):411-20. doi: 10.1016/0960-5428(95)00025-9.
Recent observations suggest that apoptosis, the natural, active cell death process is also triggered in several pathological conditions including ischemic brain insult, and neuro-degenerative and autoimmune diseases. We have investigated the mechanisms involved in the development of apoptosis in neuronal and pancreatic cells and in macrophages, which were exposed to either chemical donors of nitric oxide or to inducers of the nitric oxide synthase. In this overview, we summarize current evidence for the involvement of apoptosis in the cytotoxicity of nitric oxide and discuss possible mechanisms that may lead to cell death.
最近的观察结果表明，细胞凋亡这种自然的、主动的细胞死亡过程，在包括缺血性脑损伤、神经退行性疾病和自身免疫性疾病在内的多种病理状况下也会被触发。我们已经研究了神经元细胞、胰腺细胞和巨噬细胞中细胞凋亡发生发展所涉及的机制，这些细胞暴露于一氧化氮的化学供体或一氧化氮合酶诱导剂中。在本综述中，我们总结了目前关于细胞凋亡参与一氧化氮细胞毒性的证据，并讨论了可能导致细胞死亡的机制。
