Cifone M G, Cironi L, Meccia M A, Roncaioli P, Festuccia C, De Nuntiis G, D'Aló S, Santoni A
Department of Experimental Medicine, University of L'Aquila, Coppito, Italy.
Adv Neuroimmunol. 1995;5(4):443-61. doi: 10.1016/0960-5428(95)00028-3.
Strong and increasing evidence shows that nitric oxide (NO) contributes to immune function, and in particular to 'non-specific host defense'. The aim of the present review was to focus the current understanding of the role of NO as a biochemical effector of L-arginine-dependent cell-mediated immune responses to neoplastic cells in vitro and in vivo. The cytokine-inducible nitric oxide synthase (NOS) seems to mainly be implicated in the cytotoxic activity of almost all the effector cells involved in tumor cell killing. The cytotoxic actions of NO against tumor cells appear to be related mainly to inhibition of several heme-containing enzymes of the mitochondrial electron transport complex and the citric acid cycle.
越来越多的确凿证据表明，一氧化氮（NO）有助于免疫功能，尤其是“非特异性宿主防御”。本综述的目的是聚焦当前对NO作为L-精氨酸依赖性细胞介导的针对肿瘤细胞的体外和体内免疫反应的生化效应物的作用的理解。细胞因子诱导型一氧化氮合酶（NOS）似乎主要参与几乎所有参与肿瘤细胞杀伤的效应细胞的细胞毒性活性。NO对肿瘤细胞的细胞毒性作用似乎主要与抑制线粒体电子传递复合体和柠檬酸循环的几种含血红素酶有关。
