Runcie M J, Ulman L G, Potter E K
Prince of Wales Medical Research Institute, Prince of Wales Hospital, Sydney, NSW, Australia.
Regul Pept. 1995 Dec 14;60(2-3):193-200. doi: 10.1016/0167-0115(95)00131-x.
This study examines some of the cardiovascular and respiratory effects of pituitary adenylate cyclase-activating polypeptide (PACAP) in anaesthetised dogs. Intravenous injection of PACAP 27 caused an increase in arterial blood pressure and an increase in heart rate. The blood pressure response was significantly reduced by adrenoceptor blockade suggesting a mechanism of action mediated in part via catecholamines. The heart rate increase was unaltered by adrenoceptor blockade suggesting a direct effect of PACAP 27. PACAP 27 also caused potentiation of cardiac slowing caused by stimulation of the vagus nerve. In addition, PACAP 27 powerfully stimulated breathing. This was probably evoked by stimulation of arterial chemoreceptors, because bilateral section of the carotid sinus nerves abolished this effect. PACAP 27 had no effect on the ability of the cardiac sympathetic nerve to increase heart rate, nor on the interaction between the sympathetic and parasympathetic systems in the heart.
本研究考察了垂体腺苷酸环化酶激活多肽（PACAP）对麻醉犬心血管和呼吸系统的一些影响。静脉注射PACAP 27可导致动脉血压升高和心率加快。肾上腺素能受体阻断可显著降低血压反应，提示其作用机制部分通过儿茶酚胺介导。肾上腺素能受体阻断未改变心率加快的现象，提示PACAP 27有直接作用。PACAP 27还可增强迷走神经刺激引起的心脏减慢。此外，PACAP 27强烈刺激呼吸。这可能是由动脉化学感受器刺激引起的，因为双侧切断颈动脉窦神经可消除这种效应。PACAP 27对心脏交感神经增加心率的能力以及心脏交感和副交感神经系统之间的相互作用均无影响。
