Suzuki Y, Kasai K, Iino I, Takekoshi K, Oka M, Shimoda S
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
Life Sci. 1994;54(22):PL389-94. doi: 10.1016/0024-3205(94)00617-2.
Effects of pituitary adenylate cyclase activating polypeptide with 38 amino acid residues (PACAP-38) on both cardiovascular functions and plasma hormone levels during endotoxin shock were studied in anesthetized dogs. When PACAP-38 (a bolus 420 pmol/kg injection or a bolus 420 pmol/kg injection followed by a continuous 30 pmol/kg/min infusion for 60 min) was administered intravenously 5 min after application of endotoxin, both mean arterial pressure and cardiac output were restored at 10 min. The continuous administration of PACAP-38 was more effective in improving the symptoms of shock. Plasma adrenalin and cortisol levels were significantly increased by both regimens. These results clearly indicate that the anti-shock properties of PACAP-38 may be attributed to its abilities to increase plasma cortisol and adrenalin levels and to stimulate cardiac function.
在麻醉犬身上研究了38个氨基酸残基的垂体腺苷酸环化酶激活多肽（PACAP - 38）对内毒素休克期间心血管功能和血浆激素水平的影响。在内毒素应用5分钟后静脉注射PACAP - 38（单次推注420 pmol/kg或单次推注420 pmol/kg后持续以30 pmol/kg/min输注60分钟），10分钟时平均动脉压和心输出量均恢复。持续给予PACAP - 38在改善休克症状方面更有效。两种给药方案均使血浆肾上腺素和皮质醇水平显著升高。这些结果清楚地表明，PACAP - 38的抗休克特性可能归因于其增加血浆皮质醇和肾上腺素水平以及刺激心脏功能的能力。
