Loría-Cortés R, Quesada-Calvo E, Cordero-Chaverri C
J Pediatr. 1977 Jul;91(1):43-7. doi: 10.1016/s0022-3476(77)80441-1.
We have observed 26 cases of osteopetrosis among 165,594 children hospitalized over a period of 10 years in the National Children's Hospital. The hospital serves Costa Rica, a country of nearly 2,000,000 inhabitants with 60,000 live births per year. All patients had characteristic roentgenographic bony changes. Among the early manifestations of the disease, nasal obstruction and an adenoidal expression were common. The facial appearance of the patient is characteristic. Serious complications of the disease are hematologic and neurologic disorders.
在国立儿童医院10年期间收治的165594名儿童中，我们观察到26例骨硬化症患者。该医院服务于哥斯达黎加，该国人口近200万，每年有60000例活产。所有患者均有典型的X线骨质改变。在该病的早期表现中，鼻塞和腺样体面容很常见。患者的面部外观具有特征性。该病的严重并发症是血液学和神经学紊乱。
