Bustillo M, Stern J J, Coulam C B
Genetics and IVF Institute, Fairfax, VA 22031, USA.
Hum Reprod. 1995 Nov;10(11):2862-7. doi: 10.1093/oxfordjournals.humrep.a135808.
Controversy exists as to whether the serum concentration of progesterone on the day of human chorionic gonadotrophin (HCG) administration following ovarian stimulation for in-vitro fertilization (IVF) and embryo transfer can be used to predict the likelihood of success. This retrospective study was undertaken to answer this question by analysing a large population of IVF and embryo transfer cycles (n = 756). In addition to the concentration of progesterone on the day of HCG administration, all variables known to impact on IVF and embryo transfer success (such as patient age), indication for IVF and embryo transfer, number of oocytes retrieved and the number of embryos generated and transferred were examined. There was a significant increase in the number of oocytes retrieved with increasing progesterone concentration at the time of HCG administration. However, there was no correlation of progesterone concentration at HCG administration with pregnancy and implantation rates. It is concluded that previous reports associating a slight elevation of progesterone in gonadotrophin-releasing hormone agonist ovarian stimulation cycles for IVF and embryo transfer may be misleading because of a small sample size or the presence of confounding variables that affect IVF and embryo transfer success.
对于在体外受精（IVF）和胚胎移植的卵巢刺激后给予人绒毛膜促性腺激素（HCG）当天的血清孕酮浓度是否可用于预测成功的可能性，存在争议。本回顾性研究通过分析大量IVF和胚胎移植周期（n = 756）来回答这个问题。除了HCG给药当天的孕酮浓度外，还检查了所有已知会影响IVF和胚胎移植成功的变量（如患者年龄）、IVF和胚胎移植的指征、回收的卵母细胞数量以及产生和移植的胚胎数量。随着HCG给药时孕酮浓度的增加，回收的卵母细胞数量显著增加。然而，HCG给药时的孕酮浓度与妊娠率和着床率无关。结论是，先前关于IVF和胚胎移植的促性腺激素释放激素激动剂卵巢刺激周期中孕酮略有升高的报道可能因样本量小或存在影响IVF和胚胎移植成功的混杂变量而产生误导。
