James W H
Galton Laboratory, University College London, UK.
Hum Reprod. 1995 Nov;10(11):3042-4. doi: 10.1093/oxfordjournals.humrep.a135843.
During the 1960s and 1970s, the maternal age-specific twinning rates were declining in England and Wales and many other countries. However, around 1980 this change reversed and since then twinning rates have been increasing. The question arises whether this increase is simply a consequence of hormonal induction of ovulation and various other techniques of assisted reproduction. The question assumes some importance because the level of "natural' twinning may be an index of reproductive (and other) health. Nationwide data on the prevalence of medically assisted conceptions are not available, so indirect methods have to be used to answer the question. It is tentatively concluded here that the "natural' twinning rate has recently been increasing in England and Wales and Belgium. These conclusions are based on two assumptions: (i) that in England and Wales, conceptions by young women are infrequently preceded by medical assistance; and (ii) in Belgium, the rate of medically assisted conceptions is not lower in East Flanders than in the rest of Belgium. Direct data on these points would test these conclusions.
在20世纪60年代和70年代,英格兰、威尔士以及许多其他国家中,按母亲年龄划分的双胞胎出生率呈下降趋势。然而,大约在1980年,这一趋势发生逆转,自那时起双胞胎出生率一直在上升。问题在于,这种增长是否仅仅是激素诱导排卵以及各种其他辅助生殖技术的结果。这个问题具有一定重要性,因为“自然”双胞胎出生率可能是生殖(及其他方面)健康的一个指标。目前尚无全国范围内关于医学辅助受孕发生率的数据,因此必须采用间接方法来回答这个问题。在此初步得出结论,在英格兰、威尔士和比利时,“自然”双胞胎出生率近期一直在上升。这些结论基于两个假设:(i)在英格兰和威尔士,年轻女性受孕很少有医学辅助的情况;(ii)在比利时,东佛兰德省医学辅助受孕的发生率不低于比利时其他地区。关于这些要点的直接数据将对这些结论进行检验。