Hyett J, Moscoso G, Nicolaides K
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK.
Hum Reprod. 1995 Nov;10(11):3045-8. doi: 10.1093/oxfordjournals.humrep.a135844.
Pathological examination of the heart and great vessels was performed in 61 specimens obtained after surgical termination of pregnancy for psychosocial indications at 9-18 weeks of gestation. The aorta and pulmonary trunk were identified and external diameters were measured at the level of, and distal to the aortic valve and pulmonary valve, the level of the aortic isthmus and thoracic aorta, and the proximal and distal ductus arteriosus. All eight vessel diameters increased linearly with gestational age and the ratio of the diameter of the aortic isthmus to that of the aortic valve or the distal ductus arteriosus also increased with gestation. Early pregnancy is characterized by rapid growth of the fetal head and this may well be the consequence of a preferential distribution of left ventricular output in favour of the head due to relative narrowing of the aortic isthmus at this gestation.
对61例因社会心理因素于妊娠9至18周行人工流产术后获取的心脏及大血管标本进行了病理检查。辨认出主动脉和肺动脉干，并在主动脉瓣和肺动脉瓣水平及其远端、主动脉峡部和胸主动脉水平以及动脉导管的近端和远端测量外径。所有八条血管直径均随孕周呈线性增加，主动脉峡部直径与主动脉瓣或动脉导管远端直径之比也随孕周增加。妊娠早期以胎儿头部快速生长为特征，这很可能是由于此孕周主动脉峡部相对狭窄，左心室输出优先分布于头部的结果。
