Komenami N, Nagai K, Thibault L
Graduate School of Human Culture, Nara, Japan.
Neuroreport. 1995 Nov 27;6(17):2321-4. doi: 10.1097/00001756-199511270-00013.
We investigated the effect of chronic infusion of neuropeptide Y (NPY) aimed at the hypothalamic suprachiasmatic nucleus (SCN) or the lateral cerebral ventricle (LCV) on food intake. The experiments were performed in adult male Wistar rats infused for 7 days with saline or NPY (10 and 100 pmol microliters-1 h-1) into the SCN (n = 18) or LCV (n = 17). Infusion of the lower dose of NPY in the SCN significantly decreased food intake, whereas infusion of the higher dose did not. There was no change in food intake specific to saline or either dose of NPY with infusion in the LCV. It is concluded that chronic infusion of NPY into the SCN at a dose of 10 pmol h-1 inhibits food intake in rats.
我们研究了向下丘脑视交叉上核（SCN）或侧脑室（LCV）长期注入神经肽Y（NPY）对食物摄入的影响。实验选用成年雄性Wistar大鼠，向SCN（n = 18）或LCV（n = 17）中注入生理盐水或NPY（10和100 pmol微升-1小时-1），持续7天。向SCN注入较低剂量的NPY可显著减少食物摄入量，而注入较高剂量则无此效果。向LCV注入生理盐水或任何剂量的NPY对食物摄入量均无影响。结论是，以10 pmol小时-1的剂量向SCN长期注入NPY可抑制大鼠的食物摄入。
