Exposito I, Mora F, Zisapel N, Oaknin S
Department of Biochemistry and Molecular Biology, University of La Laguna, Tenerife, Spain.
Neuroreport. 1995 Nov 27;6(17):2399-403. doi: 10.1097/00001756-199511270-00029.
We investigated the effects of melatonin on the dopamine-glutamate interaction in the anterior hypothalamus of young, middle-aged and aged rats. In young rats, under the effects of amphetamine, melatonin produced an inhibition of dopamine release and a significant increase in glutamate and aspartate release. In middle-aged and aged rats, the inhibitory effects of melatonin on amphetamine-evoked dopamine release were maintained, but no effects on glutamate or aspartate release were found. These results suggest that, during ageing, the modulatory effect of melatonin on dopamine release in rat anterior hypothalamus is preserved whereas the dopamine-glutamate interaction is disrupted with age.
我们研究了褪黑素对年轻、中年和老年大鼠下丘脑前部多巴胺-谷氨酸相互作用的影响。在年轻大鼠中，在苯丙胺的作用下，褪黑素抑制多巴胺释放，并使谷氨酸和天冬氨酸释放显著增加。在中年和老年大鼠中，褪黑素对苯丙胺诱发的多巴胺释放的抑制作用得以维持，但未发现对谷氨酸或天冬氨酸释放有影响。这些结果表明，在衰老过程中，褪黑素对大鼠下丘脑前部多巴胺释放的调节作用得以保留，而多巴胺-谷氨酸相互作用随年龄增长而受到破坏。
