Bacilious N, Kulber D A, Peters E D, Gayle L B, Chen M J, Harper A D, Hoffman L
New York Hospital-Cornell Medical Center, New York, USA.
Microsurgery. 1995;16(9):646-9. doi: 10.1002/micr.1920160911.
A common complication of soft tissue dissection and muscle harvesting is seroma formation. In order to manage and understand the formation of seromas, we developed a small animal model for seromas in the Sprague Dawley rat. Skin flaps and subcutaneous tissue were elevated and the latissimus dorsi muscle was harvested in 20 animals. Eighteen of the 20 rats (90%) formed clinically significant seromas. Sixteen animals had associated skin flap necrosis and 12 required serial drainage for recurrent seromas. At necropsy, gross capsular formation occurred in all animals who developed seromas. Microscopically, a fibrous capsule enveloping the seroma was seen associated with a local chronic inflammatory cell infiltrate. We conclude: (1) Elevation of the latissimus dorsi muscle in the rat is a reliable and practical animal model for seroma formation; (2) Sequelae of clinically significant seromas are often as severe as skin flap necrosis; (3) An inflammatory reaction may be associated with seromas.
软组织解剖和肌肉采集的一个常见并发症是血清肿形成。为了处理和了解血清肿的形成，我们在斯普拉格-道利大鼠中建立了一个血清肿的小动物模型。在20只动物中掀起皮瓣并采集背阔肌。20只大鼠中有18只（90%）形成了具有临床意义的血清肿。16只动物伴有皮瓣坏死，12只因血清肿复发需要多次引流。尸检时，所有发生血清肿的动物均出现肉眼可见的包膜形成。显微镜下，可见包裹血清肿的纤维包膜伴有局部慢性炎性细胞浸润。我们得出结论：（1）大鼠背阔肌掀起是血清肿形成的可靠且实用的动物模型；（2）具有临床意义的血清肿的后遗症通常与皮瓣坏死一样严重；（3）炎症反应可能与血清肿有关。
