Misu Y, Yue J L, Miyamae T, Goshima Y
Department of Pharmacology, Yokohama City University School of Medicine, Japan.
Hypertens Res. 1995 Dec;18(4):267-77. doi: 10.1291/hypres.18.267.
Recent findings have enhanced our understanding of the roles played by the L-DOPA system in the baroreceptor reflex and in blood pressure regulation in the lower brainstem. L-DOPA is probably a neurotransmitter of primary baroreceptor afferents terminating in depressor sites of the nucleus tractus solitarii (NTS). It also seems to be a neurotransmitter in depressor sites of the caudal ventrolateral medulla (CVLM) and in pressor sites of the rostral ventrolateral medulla (RVLM) of normotensive Wistar rats. We have explored whether or not presynaptic and postsynaptic functions of the L-DOPA system in these areas are altered to maintain hypertension in adult spontaneously hypertensive rats, as compared with age-matched Wistar Kyoto rats. In this review article, we survey the roles of the L-DOPA system in the baroreceptor reflex and in blood pressure regulation in the rat lower brainstem.
最近的研究结果加深了我们对L-多巴系统在压力感受器反射和低位脑干血压调节中所起作用的理解。L-多巴可能是终止于孤束核（NTS）减压部位的初级压力感受器传入神经的神经递质。在血压正常的Wistar大鼠中，它似乎也是尾侧腹外侧延髓（CVLM）减压部位和头侧腹外侧延髓（RVLM）升压部位的神经递质。我们探讨了与年龄匹配的Wistar Kyoto大鼠相比，成年自发性高血压大鼠这些区域中L-多巴系统的突触前和突触后功能是否发生改变以维持高血压状态。在这篇综述文章中，我们概述了L-多巴系统在大鼠低位脑干压力感受器反射和血压调节中的作用。
