Tomoda A, Miike T, Matsukura M
Department of Child Development, Kumamoto University School of Medicine, Japan.
Brain Dev. 1995 Nov-Dec;17(6):428-31. doi: 10.1016/0387-7604(95)00083-6.
A 13-year-old male with adrenoleukodystrophy (ALD) developed a sleep-wake disorder after complete vision loss. He had a 25-h sleep-wake cycle. After methyl B12 therapy, circadian rhythms in his plasma melatonin and beta-endorphin levels approximated those of healthy volunteers, and his peak cortisol time shifted backward. Daily deep body temperature (DBT) amplitude was smaller than in healthy males before and after the treatment, and his acrophase did not change. However, his sleep-wake rhythm became normal. Methyl B12 is considered useful for treating circadian rhythm disturbances in patients having central nervous system disorders and blindness.
一名13岁患肾上腺脑白质营养不良（ALD）的男性在完全失明后出现了睡眠-觉醒障碍。他有25小时的睡眠-觉醒周期。接受甲钴胺治疗后，其血浆褪黑素和β-内啡肽水平的昼夜节律接近健康志愿者，且其皮质醇峰值时间向后推移。治疗前后，其每日深部体温（DBT）振幅均小于健康男性，且其体温高峰相位未改变。然而，他的睡眠-觉醒节律恢复了正常。甲钴胺被认为对治疗患有中枢神经系统疾病和失明患者的昼夜节律紊乱有用。
