Fabris C, Falleti E, Pirisi M, Soardo G, Toniutto P, Vitulli D, Bortolotti N, Gonano F, Bartoli E
Department of Experimental and Clinical Pathology and Medicine, University of Udine, Italy.
Clin Chim Acta. 1995 Dec 15;243(1):25-33. doi: 10.1016/0009-8981(95)06150-9.
Sialyl-Lewisa antigen (SLe(a)), the immune determinant of carbohydrate antigen 19-9 (CA 19-9), is the ligand of E-selectin. To verify the possibility of an association between nonspecific elevation of CA 19-9 and adhesion molecules, sera from 12 patients with acute hepatitis, 55 with non-cirrhotic chronic liver disease, 33 with cirrhosis and 25 with hepatocellular carcinoma, were tested for common liver function tests. Besides, CA 19-9 and soluble forms of E-selectin, VCAM-1 and ICAM-1 were measured immunoenzymatically. One-way analysis of variance demonstrated that mean CA 19-9 concentration differed among groups (F 15.27, P < 0.0001) with the highest values found in patients with acute hepatitis. By univariate analysis, the strongest correlation of CA 19-9 was with soluble ICAM-1, which by stepwise multiple regression analysis was the only independent predictor of elevated CA 19-9 (multiple R 0.560). The association between ICAM-1 and CA 19-9 might originate in the biliary cells where they might be simultaneously overexpressed during inflammatory processes.
唾液酸化路易斯抗原a（SLe(a)）是糖类抗原19-9（CA 19-9）的免疫决定簇，也是E-选择素的配体。为了验证CA 19-9非特异性升高与黏附分子之间关联的可能性，我们检测了12例急性肝炎患者、55例非肝硬化慢性肝病患者、33例肝硬化患者和25例肝细胞癌患者血清的常规肝功能指标。此外，采用免疫酶法检测了CA 19-9以及E-选择素、血管细胞黏附分子1（VCAM-1）和细胞间黏附分子1（ICAM-1）的可溶性形式。单因素方差分析表明，各组间CA 19-9的平均浓度存在差异（F = 15.27，P < 0.0001），急性肝炎患者中的CA 19-9浓度最高。单变量分析显示，CA 19-9与可溶性ICAM-1的相关性最强，逐步多元回归分析表明，可溶性ICAM-1是CA 19-9升高的唯一独立预测因子（复相关系数R = 0.560）。ICAM-1与CA 19-9之间的关联可能源于胆管细胞，在炎症过程中它们可能同时过度表达。
