Evans M J, Blessing K, Gray E S
Department of Pathology, Aberdeen University, Foresterhill, Scotland.
Pediatr Dermatol. 1995 Dec;12(4):307-10. doi: 10.1111/j.1525-1470.1995.tb00189.x.
Twenty-one cases of subepidermal calcific nodule are presented. These lesions occur twice as commonly in males compared to females, with the head (particularly the ear), and neck as favored locations. No case was identified correctly clinically and only 1 case had a history of trauma, which appeared unrelated to the lesion. Histologically, there was a variety of appearances, with two-thirds of specimens exhibiting a warty architecture. Younger lesions were composed of large, amorphous, calcific dermal deposits and were frequently associated with epidermal ulceration. The older lesions were not ulcerated and the calcium deposits were in small spherules. There was no evidence of pilomatrixoma or pre-existing nevus. It is hypothesized that subepidermal calcified nodule represents dystrophic calcification secondary to dermal injury-several in our series showed the architectural changes of verruca vulgaris.
本文报告了21例表皮下钙化结节。这些病变在男性中的发生率是女性的两倍，好发于头部（尤其是耳部）和颈部。临床上无一例被正确诊断，只有1例有外伤史，但外伤似乎与病变无关。组织学上，病变表现多样，三分之二的标本呈现疣状结构。较年轻的病变由大的、无定形的真皮钙化沉积物组成，常伴有表皮溃疡。较老的病变无溃疡，钙沉积物呈小球状。没有证据表明存在毛母质瘤或先前存在的痣。据推测，表皮下钙化结节代表皮肤损伤继发的营养不良性钙化——我们系列中的几例显示有寻常疣的结构改变。
