Herr D W, King D, Barone S, Crofton K M
Nation Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency Research Triangle Park, NC 27711, USA.
Neurotoxicol Teratol. 1995 Nov-Dec;17(6):645-56. doi: 10.1016/0892-0362(95)02007-1.
3,3'-Iminodipropionitrile (IDPN) is a neurotoxicant that produces changes in flash evoked potentials (FEPs) 18 weeks after treatment. We examined dose- and time-related effects of IDPN on FEPs at earlier time points than previously studied (52). Adult male Long-Evans rats were given IDPN (0, 100, 200, 400 mg/kg/day x 3 days, i.p.) and FEPs were recorded 14 days later. IDPN (400 mg/kg/day) decreased the amplitudes of some of the "early" and "middle" FEP peaks (n30 and N56), and increased the latencies of some early peaks (P21 and P46). A separate group of rats was treated with IDPN (0 or 400 mg/kg/day x 3 days, i.p.) and FEPs were recorded 1, 3, 7, 14, and 35 days later. The latencies of of all portions of FEPs were increased by IDPN, with maximal changes occurring at 7 and/or 14 days. The amplitude of the middle portions of FEPs (peaks N56, P63, N70, P90) were altered as early as day 3, and some changes were observed up to day 14. In contrast, the "late" portion of FEPs (peak N160) was affected at later times (days 14 and 35). Corneal opacities were noted on days 3 and 7, but were largely reversible by day 14. In the time-course study, IDPN decreased colonic temperature on days 1, 3, 7, and 14. The present results suggest that IDPN alters both the early FEP peaks related to the initial afferent sensory volley, and cortical processing associated with the middle and later portions of FEPs.
3,3'-亚氨基二丙腈（IDPN）是一种神经毒物，在治疗18周后会引起闪光诱发电位（FEP）的变化。我们在比之前研究（52）更早的时间点检查了IDPN对FEP的剂量和时间相关影响。成年雄性Long-Evans大鼠接受IDPN（0、100、200、400mg/kg/天×3天，腹腔注射），并在14天后记录FEP。IDPN（400mg/kg/天）降低了一些“早期”和“中期”FEP波峰（n30和N56）的振幅，并增加了一些早期波峰（P21和P46）的潜伏期。另一组大鼠接受IDPN（0或400mg/kg/天×3天，腹腔注射），并在1、3、7、14和35天后记录FEP。IDPN增加了FEP所有部分的潜伏期，最大变化发生在7天和/或14天。FEP中期部分（波峰N56、P63、N70、P90）的振幅早在第3天就发生了改变，直到第14天仍观察到一些变化。相比之下，FEP的“晚期”部分（波峰N160）在较晚时间（第14天和35天）受到影响。在第3天和第7天观察到角膜混浊，但在第14天基本可逆。在时间进程研究中，IDPN在第1、3、7和14天降低了结肠温度。目前的结果表明，IDPN改变了与初始传入感觉冲动相关的早期FEP波峰，以及与FEP中期和晚期部分相关的皮质处理。
