Dendale P A, Franken P R, Waldman G J, Baur L H, Vandamme S, van der Geest R J, De Roos A
Department of Cardiology, Academic Hospital VUB, Brussels, Belgium.
Coron Artery Dis. 1995 Sep;6(9):723-9.
Regional variability in systolic and diastolic cardiac function occurs in most cardiac disorders. The influence of this regional functional heterogeneity on global function is not well understood and is difficult to study with the common imaging modalities.
A midventricular short axis slice of the left ventricle was obtained with ECG-triggered magnetic resonance imaging in eight infarct patients and 10 control volunteers. The variation in wall thickness and slice cavity volume during the cycle was studied using the centreline method.
The peak filling rate was significantly decreased in the infarct group (96 versus 58 cm3/s, P < 0.005). In addition, a small contribution of other parameters, such as the time to end systole, the isovolumic relaxation time, and the duration and extent of early filling, was also shown by linear discriminant analysis. Analysis of the regional parameters demonstrated an increased asynchronicity of contraction (64 versus 37 ms, P < 0.01) as well as relaxation (88 versus 51 ms, P < 0.01) in patients with myocardial infarction. On comparison of the anterior (infarcted) and inferior (non-infarcted) parts of the left ventricle, the difference was present only in the infarct region.
Magnetic resonance imaging of the heart allows evaluation of the relationship between regional differences in wall motion dynamics and global parameters of diastolic function in infarct patients.
大多数心脏疾病中均存在心脏收缩和舒张功能的区域变异性。这种区域功能异质性对整体功能的影响尚未完全明确，且使用常规成像方式难以进行研究。
利用心电图触发的磁共振成像技术，获取了8例梗死患者和10名对照志愿者左心室的心室中部短轴切片。采用中心线法研究心动周期中室壁厚度和切片腔容积的变化。
梗死组的峰值充盈率显著降低（96对58 cm³/s，P < 0.005）。此外，线性判别分析还显示了其他参数的微小贡献，如收缩末期时间、等容舒张时间以及早期充盈的持续时间和范围。对区域参数的分析表明，心肌梗死患者的收缩异步性增加（64对37 ms，P < 0.01）以及舒张异步性增加（88对51 ms，P < 0.01）。比较左心室的前部（梗死）和下部（非梗死）部分，差异仅存在于梗死区域。
心脏磁共振成像能够评估梗死患者室壁运动动力学的区域差异与舒张功能整体参数之间的关系。
