Miyaoka H, Kamijima K
Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan.
Int Clin Psychopharmacol. 1995 Nov;10(4):265-7.
This report describes a case of encephalopathy developed in the course of amitriptyline therapy, during a remission of unipolar depression. This patient could have been diagnosed as having either neuroleptic malignant syndrome (NMS) or serotonin syndrome (SS). The major determinant of the symptoms may have been dopamine/serotonin imbalance in the central nervous system. The NMS-like encephalopathy that develops in association with the use of antidepressants indicates that NMS and SS are spectrum disorders induced by drugs with both antidopaminergic and serotonergic effects.
本报告描述了一例在单相抑郁症缓解期接受阿米替林治疗过程中发生脑病的病例。该患者可能被诊断为患有抗精神病药物恶性综合征（NMS）或5-羟色胺综合征（SS）。症状的主要决定因素可能是中枢神经系统中多巴胺/5-羟色胺失衡。与使用抗抑郁药相关的类NMS脑病表明，NMS和SS是由具有抗多巴胺能和5-羟色胺能作用的药物引起的谱系障碍。
