Reed D E, Akester J M, Prather J F, Tuckosh J R, McCurdy D H, Yeh C
J Pharmacol Exp Ther. 1977 Jul;202(1):32-7.
Rat blood and various tissues were analyzed for levels of isosorbide dinitrate (ISDN), an antianginal drug, after the administration of 14C-labeled compound. Unaltered [14C]ISDN was found in all tissues analyzed and in the circulating blood for up to 4 hours after p.o. or i.v. administration. These results clearly show that ISDN is not completely degraded in a single pass through the liver after either route of administration. ISDN concentration (nanograms of ISDN per gram wet weight of tissue) in vascular tissue were significantly greater than other tissues or the blood.
在给予14C标记的化合物后，对大鼠血液和各种组织进行了抗心绞痛药物硝酸异山梨酯（ISDN）水平的分析。口服或静脉注射后长达4小时，在所有分析的组织和循环血液中均发现未改变的[14C]ISDN。这些结果清楚地表明，无论采用哪种给药途径，ISDN在单次通过肝脏时都不会完全降解。血管组织中的ISDN浓度（每克组织湿重中ISDN的纳克数）显著高于其他组织或血液。
