Lindower J O, Marks B H
J Pharmacol Exp Ther. 1977 Jul;202(1):76-88.
Ultrastructural changes in the region adjacent to the nuclear pole were identified in the ventricular myocardium of ouabain-treated guinea pigs after 1 to 4 hours of treatment. Significant changes include expansion of the Golgi complex, an increase in the number of coated vesicles and an increase in the number of cytoplasmic particulates including glycogen particles and ribosomes. The coated vesicles appear to coalesce with the internal terminal regions of T-tubules and thereby may contribute to increase tubular mass or surface. In contrast to acute ouabain treatment, the morphologic change identified with the administration of another positive inotropic drug, isoproterenol, consists of some increase in cytoplasmic particulates, but no significant change in the Golgi apparatus or in the number of coated vesicles compared with control hearts. It is concluded that the administration of ouabain leads to activation of the Golgi complex, possibly associated with the synthesis of new T-tubular membrane components.
在哇巴因处理豚鼠1至4小时后，在心室心肌细胞核极附近区域发现了超微结构变化。显著变化包括高尔基体复合体扩张、被膜小泡数量增加以及包括糖原颗粒和核糖体在内的细胞质颗粒数量增加。被膜小泡似乎与横管的内部终末区域融合，从而可能有助于增加横管的质量或表面积。与急性哇巴因处理不同，使用另一种正性肌力药物异丙肾上腺素后所识别出的形态学变化包括细胞质颗粒有所增加，但与对照心脏相比，高尔基体或被膜小泡数量没有显著变化。得出的结论是，哇巴因给药导致高尔基体复合体激活，可能与新的横管膜成分合成有关。
