高剂量茶碱对记忆获取的影响。

Effects of high doses of theophylline on memory acquisition.

作者信息

Zarrindast M R, Jamali-Raeufy N, Shafaghi B

机构信息

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran.

出版信息

Psychopharmacology (Berl). 1995 Dec;122(3):307-11. doi: 10.1007/BF02246553.

DOI:10.1007/BF02246553

PMID:8748401

Abstract

Intraperitoneal (IP) injection of high doses of theophylline decreased memory acquisition dose dependently. Low but not high doses of the dopamine receptor D2 antagonist sulpiride and the dopamine D1 receptor antagonist SCH 23390 decreased the theophylline response. Pimozide and the beta-adrenoreceptor propranolol also decreased the drug response. The anti-muscarinic agent atropine, the alpha-adrenoceptor phenoxybenzamine and the 5-HT antagonist metergoline did not affect the response induced by theophylline. It is concluded that dopamine and beta-adrenergic receptor mechanisms may be involved in the theophylline-induced attenuation of memory acquisition.

摘要

腹腔注射高剂量的茶碱会剂量依赖性地降低记忆获得能力。低剂量而非高剂量的多巴胺受体D2拮抗剂舒必利以及多巴胺D1受体拮抗剂SCH 23390会降低茶碱反应。匹莫齐特和β-肾上腺素能受体阻滞剂普萘洛尔也会降低药物反应。抗毒蕈碱剂阿托品、α-肾上腺素能受体阻滞剂酚苄明以及5-羟色胺拮抗剂麦角新碱不影响茶碱诱导的反应。得出的结论是，多巴胺和β-肾上腺素能受体机制可能参与了茶碱诱导的记忆获得减弱过程。