Kearney J A, Albin R L
Neuroscience Program and Department of Neurology, University of Michigan, Ann Arbor, MI 48104-1687, USA.
Eur J Pharmacol. 1995 Dec 12;287(2):115-20. doi: 10.1016/0014-2999(95)00479-3.
Systemic pretreatment with the adenosine receptor antagonist theophylline significantly decreases contralateral rotation induced by unilateral intrastriatal 1-aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R-ACPD). Intrastriatal or intrasubthalamic nucleus coadministration of theophylline and 1S,3R-ACPD significantly decreases contralateral rotation suggesting that metabotropic glutamate (mGlu) receptors and adenosine receptors interact locally. These appear to be adenosine A2 receptor effects as the adenosine A2 receptor antagonist 8-(3-chlorostyryl)caffeine (CSC) also decreases contralateral rotation induced by unilateral intrastriatal and intrasubthalamic nucleus administration of 1S,3R-ACPD, while the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) has no effect. Pretreatment with the adenosine A2 receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamido adenosine hydrochloride (CGS 21680) potentiates contralateral rotation induced by unilateral striatal 1S,3R-ACPD, whereas pretreatment with the adenosine A1 receptor agonist N6-cyclopentyl-adenosine (CPA) has no effect. These results suggest that mGlu receptor effects may be due, in part, to modulation of adenosine action.
用腺苷受体拮抗剂茶碱进行全身预处理可显著降低由单侧纹状体内注射1-氨基环戊烷-1S,3R-二羧酸（1S,3R-ACPD）诱导的对侧旋转。纹状体内或丘脑底核内共同给予茶碱和1S,3R-ACPD可显著降低对侧旋转，这表明代谢型谷氨酸（mGlu）受体和腺苷受体在局部相互作用。这些似乎是腺苷A2受体的作用，因为腺苷A2受体拮抗剂8-（3-氯苯乙烯基）咖啡因（CSC）也可降低由单侧纹状体内和丘脑底核内注射1S,3R-ACPD诱导的对侧旋转，而腺苷A1受体拮抗剂8-环戊基-1,3-二丙基黄嘌呤（DPCPX）则无作用。用腺苷A2受体激动剂2-对-（2-羧乙基）苯乙氨基-5'-N-乙基羧酰胺基腺苷盐酸盐（CGS 21680）进行预处理可增强由单侧纹状体1S,3R-ACPD诱导的对侧旋转，而用腺苷A1受体激动剂N6-环戊基腺苷（CPA）进行预处理则无作用。这些结果表明，mGlu受体的作用可能部分归因于对腺苷作用的调节。
