豚鼠巨细胞病毒感染后的前庭变化。

Vestibular changes after guinea pig cytomegalovirus infection.

作者信息

Young Y H, Nomura Y

机构信息

Department of Otolaryngology, National Taiwan University, Taipai.

出版信息

Acta Otolaryngol Suppl. 1995;520 Pt 1:157-9. doi: 10.3109/00016489509125216.

DOI:10.3109/00016489509125216

PMID:8749107

Abstract

A guinea pig model of viral labyrinthitis was established by inoculating guinea pig cytomegalovirus into the inner ear and then determine its effect on vestibular function. Neither spontaneous nor positional nystagmus could be detected postoperatively. Nine out of 18 (50%) animals had caloric hyperfunction in the virus-inoculated ear at 1 to 3 weeks postoperatively. Five of these 9 animals also had caloric hyperfunction in the control ear. A morphological study in animals with caloric hyperfunction showed no change in the peripheral vestibular apparatus by light microscopy. It is thus assumed that caloric hyperfunction in experimental viral labyrinthitis is transient and functional.

摘要

通过将豚鼠巨细胞病毒接种到内耳建立病毒性迷路炎的豚鼠模型，然后确定其对前庭功能的影响。术后未检测到自发性或位置性眼球震颤。18只动物中有9只（50%）在术后1至3周时接种病毒的耳朵出现冷热试验功能亢进。这9只动物中有5只对照耳也出现冷热试验功能亢进。对冷热试验功能亢进动物的形态学研究显示，光镜下外周前庭器官无变化。因此推测，实验性病毒性迷路炎中的冷热试验功能亢进是短暂的且为功能性的。